Dual-action W1/O/W2 nanoemulsion gel for enhanced transdermal nerve pain relief

Overview

The dual-action W1/O/W2 nanoemulsion gel represents a significant advancement in transdermal nerve pain relief solutions. Combining a hyper-saline Magnesium Chloride core with a Menthol-based counter-irritant, this formulation is designed to deliver rapid and effective pain relief directly to epidermal nociceptors. The novel double-emulsion structure ensures that the active ingredients bypass the stratum corneum through the follicular shunt route, reducing typical skin irritation associated with high magnesium concentrations.

Technical specifications

Key features:

• Utilizes a valve-based high-pressure homogenizer to create sub-micron droplets for effective encapsulation.
• The hyper-saline Magnesium Chloride core is protected by a stable lipophilic lipid matrix, minimizing osmotic shock and irritation.
• Menthol is dissolved in the oil phase, acting as a permeation enhancer to boost transdermal absorption.
• Non-ionic steric stabilizers in the external water phase ensure structural stability and effective delivery.
• Designed as a non-greasy "Magnesium Milk" hydrogel for high consumer compliance.

Technology readiness level

The technology is currently at TRL 4, with core double-emulsion optimization, physicochemical characterization, and industrial scale-up validation underway. Future steps include pilot scale-up and IP validation to ensure readiness for commercial application.