Dual nanotechnology solutions for whitening and enamel repair
Innovative dual-action toothpaste and bleaching gel using activated carbon and bioactive glass nanoparticles for effective whitening and enamel repair without sensitivity. Validated through in vitro analyses with plans for preclinical trials and pilot-scale production.
Overview
This solution involves two nanotechnology-based formulations designed to enhance dental whitening while preserving enamel integrity and reducing sensitivity. The first is a daily-use toothpaste combining activated carbon and bioactive glass nanoparticles (nBG), which work together to remove stains and promote enamel recovery. The second is an in-office bleaching gel incorporating hydrogen peroxide and nBG, ensuring effective bleaching with enamel repair.
Technical specifications
- Activated Carbon (AC): A high-surface-area adsorbent that physically removes extrinsic stains, leading to visible whitening.
- Bioactive Glass Nanoparticles (nBG): These nanoparticles induce hydroxyapatite formation, sealing dentinal tubules and reducing sensitivity.
- Hydrogen Peroxide Bleaching Gel: Incorporates nBG to mitigate enamel demineralization and support mineral restoration post-bleaching.
- Validation: SEM and EDX analyses confirm over 90% dentinal tubule occlusion and significant Ca/P deposition.
Technology readiness level
The solution is at TRL 4, with validated in vitro results demonstrating whitening efficacy and enamel repair. A 6-month proof-of-concept project is planned to optimize formulations for preclinical validation, with the goal of developing a pilot-ready prototype for clinical testing in collaboration with the University of Chile.
About Universidad de Chile
Universidad de Chile is a comprehensive public research university in Santiago and one of the country’s largest, with a broad academic portfolio and national reach. Industry engages through co‑located laboratories and shared facilities, a university research and technology park, and an integrated teaching hospital that enables clinical translation. Its urban location places partners near regulators and the headquarters of major Chilean firms, supporting agile contract research, testing services, and talent pipelines. Research is backed by Chile’s national science and innovation agencies, competitive international programs, and industry funding. A dedicated technology transfer office manages IP, licensing, and startup formation with corporate‑friendly agreements.
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