Economical biocatalytic monohydroxylation using hydregen h2biocat technology
HydRegen's H2BioCat technology offers a cost-effective, scalable solution for monohydroxylation, using selective enzymes and H2 for efficient cofactor recycling. This reduces waste and costs, enabling industrial applications with projected cost reductions of up to 40%.
Overview
HydRegen's innovative H2BioCat technology provides an economical and environmentally friendly approach to monohydroxylation, a key chemical process in industrial applications. By coupling H2BioCat with specific enzymes like P450s, FMOs, and UPOs, the technology allows for efficient, one-step hydroxylation reactions with significant cost and waste reductions. This approach leverages the clean use of hydrogen for cofactor recycling, overcoming traditional limitations of expensive cofactors and waste generation.
Technical specifications
Key features:
- Utilizes selective, redox cofactor-dependent enzymes for precise monohydroxylation
- H2BioCat system enables high reaction concentrations and straightforward downstream processing
- Co-immobilizes enzymes on carbon scaffolds, similar to metal-on-carbon catalysts
- Proven scalability and economic viability for industrial reactions
- Reduces production costs by 30-40% with a target cost of 15-20 $/kg for hydroxyl-containing products
Technology readiness level
HydRegen's H2BioCat technology currently stands at TRL 6, with successful lab-scale demonstrations. The proposed validation plan includes a 20-month phased approach for further development, scale-up, and tech transfer, aiming for pilot plant demonstration and eventual full-scale industrial application.
About HydRegen
HydRegen is a spin-out company from the University of Oxford focused on redefining chemical manufacturing using a biocatalytic platform that aims to deliver cleaner, safer, faster, and more cost-effective chemical production for sectors including pharmaceuticals and the cosmetics/food industries.
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