Enhanced stabilization method for thermosensitive biomolecules and microorganisms
This innovative method stabilizes thermosensitive biomolecules and microorganisms at high temperatures by maintaining medium viscosity above water's natural state. Ideal for preserving molecules like NADH and ATP, it supports applications in biotechnology and pharmaceuticals.
Overview
This cutting-edge stabilization method enables the preservation of thermosensitive biomolecules and microorganisms under high-temperature conditions by maintaining the viscosity of their storage medium at or above 1 mPa.s. This technique is critical for preserving molecules such as NADH and ATP, which are essential for various biochemical processes but tend to degrade at high temperatures. This approach is particularly beneficial for applications in biotechnology and pharmaceuticals where maintaining molecular integrity is crucial.
Technical specifications
- Stabilization technique: Maintains medium viscosity at or above 1 mPa.s to preserve biomolecules at temperatures up to 80ºC.
- Key biomolecules: Tested on NADH and ATP, with potential applications for other thermosensitive molecules.
- Application method: Suitable for laboratory demonstrations and real-world field conditions.
- Future testing: Includes laboratory simulations and field tests with different viscosity-increasing solutions.
Technology readiness level
The technology is currently at TRL 5, indicating that it has been validated in relevant environments and is moving towards optimization for specific applications in real-world settings.
About Consejo Superior de Investigaciones Científicas
Consejo Superior de Investigaciones Científicas (CSIC) is Spain’s national public research organization and the country’s largest R&D institution, with a nationwide network of institutes across major innovation hubs. Many labs are co‑located with universities, hospitals, and science parks, giving partners plug‑and‑play access to advanced facilities, pilot‑scale capabilities, and testing services. Industry collaborates through contract research, sponsored development, and shared core facilities, with pathways into multi‑site European consortia. Research is supported by competitive European programs and Spain’s national funding agencies. A dedicated technology transfer office manages IP, licensing, and spin‑off formation to accelerate commercialization.
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