Enhanced topical delivery system for capsaicin using z-pods for neuropathic pain relief

Overview

Zylö Therapeutics presents an innovative solution for the topical delivery of capsaicin using its patented Z-pods® technology. Designed to address neuropathic pain, this system encapsulates capsaicin in a time-release delivery format. The solution is developed as a roll-on stick, allowing for easy application without direct contact, thus preventing accidental exposure to sensitive areas such as the eyes or mouth. This method enhances the delivery of capsaicin to the epidermis and dermis, ensuring prolonged therapeutic effects and improved patient compliance.

Technical specifications

Key features:

• Utilizes Z-pods®, a patented time-release delivery system, to encapsulate capsaicin.
• Designed as a roll-on stick for convenient and safe application.
• Avoids dose-dumping issues associated with cream formulations.
• Demonstrated efficacy with no adverse effects in prior studies.
• Potential for combination with other therapeutic agents like CBD and diclofenac.

Prototype development:

• Capsaicin-loaded Z-pods at 5 wt.% have been developed.
• Stick formulations incorporating 2%, 4%, and 20% Z-pods have been optimized.
• Future validation includes in vitro release assays and ex vivo skin analysis.

Technology readiness level

Currently at Technology Readiness Level 5, the capsaicin-loaded Z-pod system has successfully moved beyond initial prototype development and is undergoing further validation. The next stages involve ex vivo and in vivo testing to verify efficacy and safety under real-world conditions.