Enzyme-responsive polyelectrolyte complexes for targeted micronutrient delivery
Innovative polyelectrolyte complexes enable targeted micronutrient delivery by encapsulating nutrients in a solid form, protecting them from harsh environments, and releasing them in response to specific enzymes. Ideal for applications requiring precise nutrient release.
Overview
This technology leverages enzyme-responsive polyelectrolyte complexes to enhance the stabilization and delivery of micronutrients. The complexes are composed of oppositely charged polymers that form a solid matrix to encapsulate nutrients, protecting them from harsh environments, such as the stomach. Upon exposure to specific enzymes, these complexes transition to a liquid state, releasing the encapsulated micronutrients precisely where needed. This targeted release mechanism offers significant advantages for applications in nutrition and pharmaceuticals, ensuring efficacy and bioavailability.
Technical specifications
The core of this technology involves the use of solid polyelectrolyte complexes formed by the interaction of oppositely charged polymers. The polymers used, such as carboxymethylcellulose (CMC) and poly(L-lysine) (PLK), form solids that transition to liquids upon enzyme interaction. This transition is facilitated by the cleaving of polymers which alters the system's thermodynamics. Initial studies have demonstrated successful encapsulation and release of model flavors using cellulase as the enzyme trigger. Key features include:
- Use of CMC and PLK for solid matrix formation
- Enzyme-triggered phase transition for targeted release
- Protection of micronutrients from external stimuli
Technology readiness level
This innovative delivery system is currently at Technology Readiness Level 2. Preliminary studies have demonstrated proof of concept, and further validation is planned to optimize polymer charge ratios and evaluate encapsulation and release of a broader range of nutrients and flavors.
About Lehigh University
Lehigh University is a private, mid-sized research university in Bethlehem, Pennsylvania focused on interdisciplinary, hands-on problem solving. A multi-campus footprint includes a research campus with co-located labs, instrumentation, and prototyping spaces for rapid iteration with industry. Corporate engagement staff streamline sponsored research, capstones, internships, and short courses, and an on-campus incubator links partners to startup pipelines. Proximity to New York City and Philadelphia enables collaboration with regional manufacturers, logistics leaders, and growth-stage firms. Faculty secure competitive federal funding from agencies such as the NSF and DOE, and a technology transfer office supports IP, licensing, and new venture formation.
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