Functionalized solid lipid nanoparticles for targeted CNS drug delivery
Innovative solid lipid nanoparticles (SLNs) functionalized for efficient blood-brain barrier penetration, offering enhanced delivery of oligonucleotides and natural therapeutics for CNS applications.
Overview
Functionalized Solid Lipid Nanoparticles (SLNs) present a groundbreaking approach for delivering therapeutic agents across the blood-brain barrier (BBB). These nanoparticles are designed to encapsulate oligonucleotides and natural compounds, utilizing receptor-mediated transcytosis for targeted delivery to central nervous system (CNS) cells. The technology promises increased delivery efficiency while minimizing systemic elimination, making it safer and more effective than traditional methods.
Technical specifications
The SLNs are engineered using cetyl-palmitate and Tween 80, with an optimal Lipid:Tween ratio that produces stable nanoparticles ranging from 120 to 160 nm with a PDI of less than 0.2. These dimensions prevent filtration and retention, enhancing systemic circulation. The nanoparticles have achieved an 82% delivery efficiency for quercetin, a natural antioxidant. Future enhancements include functionalization with TfR1 and CD98 antibodies for specific targeting and a multicomponent formulation to encapsulate both therapeutic oligonucleotides and natural compounds.
Technology readiness level
Currently at TRL 3, the technology has been validated in lipid membrane and cellular models. Ongoing research aims to further develop and validate the functionalized system in vitro and in vivo, targeting applications in neurodegenerative disease therapies.
About Tecnológico de Monterrey
Tecnológico de Monterrey is a leading private, multi-campus research university in Mexico, recognized for entrepreneurship and industry collaboration. Its Monterrey headquarters anchors an urban innovation district with open lab space, prototyping, and shared testing facilities that welcome corporate collaborators. An integrated health system supports clinical research and translation, while structured internships and challenge-driven partnerships connect companies with faculty and student talent year-round. Research is supported by competitive federal funding through Mexico’s national science and technology council, along with industry contracts and international sponsors. A dedicated technology transfer office manages IP, licensing, and startup formation.
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