Genomic identification of genetic modifiers in feline ADPKD for therapeutic insights
Leveraging genomic tools to identify genetic modifiers in cats with ADPKD, this research aims to understand disease progression and treatment variability, providing insights for human therapies.
Overview
This project explores the genetic underpinnings of autosomal dominant polycystic kidney disease (ADPKD) in cats, with the aim of identifying genetic modifiers that influence disease progression and treatment responses. By studying these modifiers, the research seeks to improve understanding of ADPKD pathology in humans, potentially leading to more effective therapies and enhanced quality of life for patients.
Technical specifications
The research utilizes advanced genomic tools, including:
- A reference genome for cats, enabling precise genetic analysis.
- Exome capture and HD arrays to identify relevant genetic variants.
- A comprehensive database of genetic variants to support bioinformatics analysis.
Through DNA and RNA approaches, this study focuses on genetic variants in a colony of cats with ADPKD, examining how these variants impact disease severity and treatment efficacy, particularly with ketogenic diets.
Technology readiness level
This research is currently at a Technology Readiness Level 5, indicating that the concept has been validated in relevant environments through controlled trials and genomic analysis of feline models.
About University of Missouri, Columbia
Founded as Missouri’s flagship land‑grant, the University of Missouri–Columbia is a comprehensive public research university serving a large student body and partners statewide. Industry engages on campus through co‑located research cores, a research park and incubator in Columbia, and access to a high‑power university research reactor supporting isotope production and advanced testing. An integrated academic health system enables clinical studies and translation, while a statewide extension and agricultural research network links companies to field sites, producers, and community testbeds across Missouri. Research is supported by competitive federal funding from agencies such as NIH, NSF, USDA, and DOE. A dedicated tech transfer office supports IP, licensing, and sponsored‑research agreements.
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