Haa-1 transcription factor inhibition for natural food preservation
Innovative approach targeting Haa-1 transcription factor in Zygosaccharomyces bailii to inhibit yeast adaptation in acidic environments, offering a natural alternative to artificial preservatives in food preservation.
Overview
The proposed solution focuses on inhibiting the Haa-1 stress response transcription factor in the yeast Zygosaccharomyces bailii to prevent its adaptation and survival in acidic conditions. This strategy aims to reduce yeast growth and mold formation, facilitating natural food preservation without artificial additives. By targeting Haa-1, the approach seeks to diminish the yeast's resilience against acidity, thereby enhancing the shelf life of food products using plant-based compounds.
Technical specifications
Key features:
- Utilizes natural compounds to inhibit the Haa-1 transcription factor, disrupting yeast adaptation mechanisms.
- Initial computational docking screened 65,000 natural molecules from the MolPort library for inhibitory potential.
- Selected plant-based compounds like 3-(3-hydroxyalkanoyloxy)alkanoic acids, Terpene glycosides, and Isoflavonoid O-glycosides.
- In vitro assays and bioinformatics tools will validate inhibitory effects and analyze gene expression changes.
- Safety profile assurance through in-house protocols.
Technology readiness level
The current technology readiness level is 2, indicating that the concept is in the early stages of research, with ongoing computational and in vitro validation efforts.
About R.V. College of Engineering
RV College of Engineering (RVCE) is an autonomous, self‑financing engineering institution in Bengaluru, affiliated to Visvesvaraya Technological University and accredited NAAC A+. It connects to industry through an active Industry Institute Interaction Cell, 150+ MoUs, and co‑located, industry‑sponsored labs and Centers of Excellence that enable joint training, prototyping, and upskilling on campus. Proximity to Bengaluru’s technology cluster supports internships, capstone co‑supervision, and consultancy engagements throughout the year. Research here is supported by competitive national programs and industry, including DRDO/NRB, AICTE, and ISRO collaborations. An IP Coordination Cell, together with incubation resources and a student‑run Entrepreneurship Development Cell, assists with patenting, licensing, and venture formation.
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