High-affinity peptides for inhibiting chitin synthase 6 in magnaporthe oryzae
Introducing high-affinity peptides designed to inhibit Chs6, a critical enzyme in Magnaporthe oryzae, using the HOPE algorithm. This approach aims to block fungal cell-wall synthesis, providing potential solutions for durable blast resistance in rice crops.
Overview
This innovative solution leverages high-affinity peptides engineered to target and inhibit chitin synthase 6 (Chs6) in Magnaporthe oryzae, a significant rice pathogen. Using the proprietary Highly Optimized Peptide Engineering (HOPE) algorithm, these peptides are designed to bind specifically to the Chs6 active site, blocking UDP-GlcNAc access and thereby inhibiting fungal cell-wall synthesis. This approach mimics the effects of a chs6 gene knockout, potentially rendering the fungus non-pathogenic and providing a novel method for controlling rice blast disease.
Technical specifications
- HOPE Algorithm: Generates a library of peptides (8–12 amino acids) targeting Chs6 active-site residues for high-specificity binding.
- In Silico Optimization: Peptides are optimized for protease resistance, fungal cell-wall penetration, and stability at room temperature.
- Validation Procedures: Includes docking simulations, molecular dynamics evaluations, and in vitro assays for Chs6 inhibition and spore germination.
- Future Development: Lead peptides may be tested in greenhouse and field trials. Potential for transgenic rice expression for built-in blast resistance.
Technology readiness level
Currently at TRL 3, this technology is in the experimental proof-of-concept stage. Initial peptide candidates have been designed and are undergoing in silico testing and in vitro validation to assess their efficacy in inhibiting Chs6 and reducing fungal pathogenicity.
About Texas A&M University, College Station
Texas A&M University in College Station is a comprehensive public research university and the flagship of The Texas A&M University System, combining broad academic strengths with a strong applied‑research culture. Industry collaborates on the Texas A&M‑RELLIS campus—an integrated education, research and testing environment that supports large‑scale experimentation and proving grounds—and through the Texas A&M Transportation Institute’s facilities in Bryan‑College Station. A statewide extension network connects university expertise to companies and communities across all Texas counties, enabling rapid piloting and deployment. Research is supported by competitive federal funding from agencies such as NSF, NIH, DOE, USDA and DoD, alongside state and industry sponsorship. Texas A&M Innovation provides IP management, licensing and commercialization pathways across the system.
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