High-throughput genomic engineering for enhanced protein secretion in yeast
Pioneer Biolabs introduces a high-throughput genomic technology to enhance protein secretion in yeast by testing thousands of genetic modifications simultaneously. This accelerates strain development and increases bioprocess success rates.
Overview
Pioneer Biolabs has developed an innovative high-throughput genomic engineering platform designed to enhance protein secretion in yeast. This cutting-edge tool allows for the simultaneous testing of tens of thousands of genetic modifications, providing researchers with comprehensive insights into optimal genetic configurations for protein production. By significantly reducing strain development times and increasing the probability of successful bioprocess scaling, this technology is poised to revolutionize the field of microbial engineering.
Technical specifications
- High-throughput capability: Capable of testing tens of thousands of genetic modifications in a single experiment.
- Enhanced insight: Provides a detailed understanding of yeast cell mechanics for targeted engineering.
- Flexible applications: Suitable for a wide range of proteins, overcoming limitations of previous technologies related to sensitivity and types of detectable modifications.
- Scalable testing environment: Initial tests conducted in bench-top bioreactors with plans to extend to more complex protein strains.
Technology readiness level
The technology is currently at TRL 3, having completed initial developmental stages. Upcoming milestones include testing in small-scale settings and developing strains for medium-complexity proteins, setting the stage for further advancements and partnerships.
About Pioneer Biolabs, Inc.
Pioneer Biolabs, Inc. is a biotechnology company founded in 2018 and based in Provo, Utah. The company specializes in microbial cell engineering, leveraging a proprietary genomics platform that utilizes high-throughput screening, such as genome-wide CRISPR screening combined with fluorescent cell sorting, to engineer and optimize microbial cells for enhanced protein production. Their technology stack includes SLALOM 1.0, a line of kits designed for the rapid synthesis of sgRNA libraries, which allows for efficient library construction even with small DNA quantities. In addition to their product offerings, the company provides custom library synthesis services through their SLALOM 1.0 PRO platform, which supports sequencing, data processing, and analytics to ensure library quality for research applications.
This technology is designed to assist companies across various sectors—including biotherapeutics, enzymes, food, textiles, and cosmetics—by significantly reducing bioprocess development times. By enabling a more precise and efficient method for rewiring cells to increase target protein yields, Pioneer Biolabs provides a competitive edge to partners looking to optimize their production strains. Through these services, the company helps organizations identify effective genomic modifications, aiming to streamline the transition from initial strain development to industrial-scale production. The company operates as a B2B service provider, offering tools and technical support to scientists and researchers engaged in complex biological engineering projects.
Inquire about this partnering listing
Industry applications
delivered to your inbox.