High throughput screening for estrogen pathway modulator identification
Advanced screening models to identify selective ligands for estrogen receptors, focusing on distinguishing between classical ER and GPER pathways.
Overview
This innovative solution involves high throughput screening models designed to identify modulators of estrogen pathways, specifically targeting the classical estrogen receptors (ER) and the G protein-coupled estrogen receptor (GPER). The goal is to discover novel selective ligands that can differentiate the pharmacology of GPER from classical ER, providing significant insights into estrogen signaling. This advancement holds potential applications in therapeutic areas relating to reproductive health and endocrine disorders.
Technical specifications
- High throughput screening models: Capable of identifying selective ER and GPER ligands.
- Ligand differentiation: Focuses on distinguishing between ERα and GPER pathways.
- Molecular docking simulations and binding assays: Used to evaluate structure-activity relationships.
- Biological analysis: Conducted in cells expressing ERα and/or GPER, including 3D organoid cultures.
- Validation: Utilizes acknowledged agonists/antagonists and engineered cell lines to assess receptor involvement.
Technology readiness level
This technology is currently at TRL 5, having undergone component and/or breadboard validation in a relevant environment. Future validation steps include further molecular analysis and biological assays to confirm the specificity and efficacy of identified compounds.
About Universita della Calabria
Università della Calabria is a comprehensive public research university in southern Italy, anchored by a residential campus that concentrates teaching, research, and advanced instrumentation. Industry partners access co-located labs, pilot-scale facilities, and shared equipment through streamlined collaboration agreements and contract R&D. The university connects with regional SMEs and multinationals via internships, industry-sponsored theses, and applied research placements, and participates in European consortia that enable cross-border development. Research is supported by competitive funding from the European Commission and national ministries, along with regional development programs. A dedicated technology transfer office manages IP, licensing, and startup formation, complemented by entrepreneurship programs and spaces for prototyping and testing.
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