High-throughput screening of natural preservatives via biotechnology

Overview

Conagen, Inc. is pioneering the development of natural preservatives through precision fermentation and bioconversion. By leveraging phenolic molecules, the company aims to replace traditional preservatives like sorbate and benzoate, meeting consumer demand for natural ingredients without compromising on efficacy. This innovative approach not only maintains acceptable organoleptic properties but also enables products to carry a "natural preservative" label, appealing to health-conscious consumers.

Technical specifications

Conagen's high-throughput screening (HTS) assay efficiently evaluates combinations of antimicrobial and antioxidant compounds. The process involves challenging a cocktail of yeasts, including Saccharomyces cerevisiae, Candida rugopelliculosa, and Zygosaccharomyces bailii, with these compounds. Synergistic combinations showing high efficacy are further tested against molds and bacteria and undergo sensory studies. The HTS system allows for testing both single and multi-component preservative formulations, initially at solubility-limited concentrations, to identify optimal natural preservative solutions.

Technology readiness level

Conagen's technology is currently at TRL 5, indicating that it has been validated in relevant environments. The company's lead natural preservatives have progressed to scale-up and regulatory filing stages, demonstrating readiness for commercial advancement.