High-throughput virtual screening of natural compounds for appetite control
A high-throughput virtual screening platform to identify natural compounds that act as GLP-1 receptor agonists for appetite regulation, offering a natural alternative to traditional medications. Targeting integration into consumer food and beverage products.
Overview
This innovative platform utilizes high-throughput virtual screening (HTVS) to discover natural compounds that can effectively serve as GLP-1 receptor agonists, aiding appetite control. By focusing on natural ingredients, the platform aims to offer a viable alternative to traditional GLP-1 medications, targeting individuals seeking to manage appetite without synthetic drugs. The solution is particularly suitable for integration into frozen foods, beverages, and snacking products, aligning with consumer trends towards natural and healthy lifestyle choices.
Technical specifications
Key features:
- Utilizes molecular docking simulations to assess binding affinity of natural compounds to GLP-1 receptors.
- Incorporates in-silico ADME (Absorption, Distribution, Metabolism, and Excretion) and toxicity predictions for safety and bioavailability assessment.
- Employs pharmacophore modeling to refine structural features of compounds for optimal appetite regulation.
- Focuses on the transition from computational studies to experimental validation for promising compounds.
Technology readiness level
The platform is currently at TRL 3, indicating that it is in the experimental proof of concept phase. The ongoing computational studies are expected to guide the selection of candidates for further experimental validation.
About R.V. College of Engineering
RV College of Engineering (RVCE) is an autonomous, self‑financing engineering institution in Bengaluru, affiliated to Visvesvaraya Technological University and accredited NAAC A+. It connects to industry through an active Industry Institute Interaction Cell, 150+ MoUs, and co‑located, industry‑sponsored labs and Centers of Excellence that enable joint training, prototyping, and upskilling on campus. Proximity to Bengaluru’s technology cluster supports internships, capstone co‑supervision, and consultancy engagements throughout the year. Research here is supported by competitive national programs and industry, including DRDO/NRB, AICTE, and ISRO collaborations. An IP Coordination Cell, together with incubation resources and a student‑run Entrepreneurship Development Cell, assists with patenting, licensing, and venture formation.
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