Host–guest network for purification of organic acids from fermentation processes
A novel polymer network with molecular cages for efficient purification of organic acids from fermentation broths, offering selective binding and removal capabilities.
Overview
Our innovative solution involves the development of a polymer network equipped with molecular cages that selectively recognize and bind organic acids. This technology is designed to purify organic acids, such as fumaric and malic acid, from fermentation processes. The inclusion of molecular cages in the polymer network allows for strong, selective hydrogen bonding, facilitating efficient separation and purification.
Technical specifications
The polymer networks are derived from low-cost polyurethanes and incorporate molecular cages capable of selectively binding small molecule organic acids. These materials can be processed into mechanically robust foams, enabling straightforward removal of acids from fermentation broths through selective host-guest complexation. A library of materials will be synthesized, using different cages to optimize the binding of various C2-C6 organic acids. The performance will be evaluated against materials without cages and other ion exchange membranes, measuring removal efficiencies and purities using spectroscopic techniques.
Technology readiness level
This technology is currently at a Technology Readiness Level (TRL) 3, indicating experimental proof of concept. Further validation is planned, involving the synthesis and testing of a library of polymers to optimize material properties and acid uptake.
About Massachusetts Institute of Technology
MIT is a private research university known for intensive, interdisciplinary discovery and a global scale of sponsored research. Industry engages through a long-standing corporate partnership program, on-campus collaboration spaces, and shared-use facilities that enable rapid prototyping and characterization. The institute also operates a federally funded R&D center and maintains close adjacency to Kendall Square, allowing company teams to embed with faculty and students and accelerate translation. Research is supported by competitive federal funding from NSF, NIH, DOE, and the Department of Defense. A dedicated technology transfer office, standardized agreements, and an affiliated deep-tech accelerator support IP, licensing, and startup formation.
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