Hyaluronan binding silk fibroin patches for enhanced wound repair
Innovative silk fibroin patches incorporating hyaluronan binding peptides to enhance wound healing post-shave injuries by reducing scarring and improving skin elasticity.
Overview
This cutting-edge solution involves the development of silk fibroin patches that incorporate hyaluronan binding peptides (HABPs) to enhance wound healing and reduce scarring from shave injuries. The combination of silk fibroin, known for its superior strength and elasticity, with HABPs aims to stimulate endogenous hyaluronic acid production, promoting scarless healing and increasing skin strength and elasticity.
Technical specifications
Key features:
- Incorporates hyaluronan binding peptides into silk fibroin patches
- Aims to boost endogenous hyaluronic acid expression for improved healing
- Designed for topical application to promote easy translation to market
Testing and Validation Plans:
- Allergy and irritation testing on ex vivo human skin biopsy samples
- Hemocompatibility tests to assess blood clotting, platelet activation, and hemolysis
Technology readiness level
This technology is currently at Technology Readiness Level 4, indicating that components have been validated in a laboratory environment.
About South Dakota School of Mines & Technology
South Dakota Mines is a STEM-focused public research university in Rapid City known for applied, industry‑aligned education and research. Companies engage through co-located labs and testbeds for advanced manufacturing and materials, a structured internship and co-op program, and sponsored senior design that channels real problem statements into prototypes. The university’s location links partners to Ellsworth Air Force Base, the Sanford Underground Research Facility in Lead, and an adjacent incubator ecosystem with regional economic development organizations. Research is backed by competitive federal awards from NSF, DOE, DOD, NASA and other agencies. A dedicated commercialization function supports IP protection, licensing, and startup formation.
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