Hydration-focused clinical protocol to enhance performance and recovery
A novel clinical trial protocol assessing hydration's impact on endurance, cognition, fatigue resistance, and recovery using innovative tools like MOXY sensors and Seahorse XF analysis. Suitable for athletes and health-conscious individuals.
Overview
This innovative clinical trial protocol aims to evaluate the effects of hydration-focused interventions on various performance and recovery measures. The study explores muscular, cardiovascular, cognitive, and molecular outcomes, hypothesizing that targeted hydration can enhance endurance, cognition, fatigue resistance, and recovery. This approach uses advanced tools like MOXY sensors for real-time tissue oxygenation tracking and Seahorse XF analysis to assess mitochondrial bioenergetics in muscle tissue, setting a new benchmark for recovery science.
Technical specifications
Key features:
- Real-time MOXY sensors for non-invasive tracking of tissue oxygenation during exercise.
- Seahorse XF analysis to measure mitochondrial bioenergetics in muscle tissue.
- Multi-omics approach including metabolomics, RNA-seq, and lipidomics for comprehensive mechanistic insights.
- Integration of cognitive function metrics with physiological data to assess the novel impact of hydration.
The protocol involves exercise trials under ambient and heat-stressed conditions, employing MOXY, VO₂ measurements, CGM, serial blood sampling, psychometric cognitive tests, and muscle biopsies.
Technology readiness level
The protocol is at Technology Readiness Level 6, having been validated in a controlled environment with plans for further data collection and analysis. Future work includes recruiting participants, baseline testing, and delivering interventions under various conditions to validate the findings further.
About University of Aberdeen
Founded in 1495, the University of Aberdeen is a comprehensive public research university in northeast Scotland, serving a mid-sized international student body. Industry engagement is enabled by the Foresterhill health campus, where researchers share a site with NHS Grampian to support clinical studies and rapid translation. Its position in the North Sea energy and offshore engineering cluster offers companies access to faculty expertise, relevant test facilities, and a talent pipeline with industrial placement experience. Research is supported by competitive awards from UK Research and Innovation councils and major UK charities, with additional support from Innovate UK and European programs. A dedicated technology transfer office supports IP, licensing, and spin‑outs, with access to incubator space and investor networks.
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