In situ ROS generating polymer as potent disinfectant

Overview

This innovation introduces a polymer-based disinfectant that generates reactive oxygen species (ROS) on demand when hydrated in an aqueous solution. Unlike conventional disinfectants, the dry powder formulation contains no pre-loaded ROS; instead, an active catechol ingredient converts dissolved molecular oxygen into ROS upon contact with water. This activation mechanism enables rapid, on-site generation of highly potent radical-containing ROS that deliver strong antimicrobial and antiviral performance. The approach allows the product to be stored as a stable dry powder and activated only when needed, offering logistical and shelf-life advantages over traditional liquid disinfectants.

Technical specifications

Key features:

• Catechol-containing polymers that generate ROS through conversion of molecular oxygen when hydrated
• Dry powder formulation remains stable until activated by water, eliminating pre-loaded oxidant concerns
• Formulation with iron ions or iron nanoparticles converts generated ROS into more potent radical-containing species
• Chemical modification of catechol increases ROS output by approximately tenfold compared to unmodified versions
• Achieved 7-log reduction of S. epidermidis and E. coli within 5 to 8 minutes at a 1:30 dilution (33 mg/mL)
• Available in coating and powder formats for diverse application surfaces and use cases

Technology readiness level

The technology has progressed through laboratory validation, with multiple formulations tested in both coating and powder forms. Current efforts are focused on enhancing catechol reactivity through chemical modification, with unpublished data showing a tenfold increase in ROS generation. Future validation will focus on synthesizing water-soluble polymeric materials with chemically modified catechol, optimizing formulation composition with iron-based enhancers, and evaluating ROS release profiles under varying pH and temperature conditions. Antimicrobial efficacy will be tested at dilutions ranging from 1:50 to 1:200 against S. epidermidis and E. coli following EN 1276 guidelines.