Inline four-channel CARS spectroscopy for lipid processing optimization

Overview

The Inline Four-Channel Coherent Anti-Stokes Raman Scattering (CARS) spectroscopy is a cutting-edge solution designed for real-time, label-free monitoring and optimization of downstream processing in fermentation-derived lipid production. This innovative technology captures four essential channels directly within the production pipeline, offering instantaneous feedback on lipid release, separation efficiency, and impurity levels. By eliminating the need for sampling or additional consumables, this system enhances lipid yield by 5-12% and reduces energy consumption by 15-25%, aligning with industrial goals of scalability, cost efficiency, and sustainability.

Technical specifications

Key features:

• Real-time, non-destructive monitoring using CARS spectroscopy
• Direct inline installation capturing four lipid-specific channels: ~1740 cm⁻¹ (carbonyl ester), ~1440 cm⁻¹ (CH₂ deformation), ~1650 cm⁻¹ (protein amide I), and background
• Automated software for calculating critical parameters and delivering actionable insights or closed-loop control signals
• Increases overall lipid yield and reduces energy and chemical usage
• Compatible with existing commercial Raman systems for easy adaptation

Technology readiness level

The technology is currently at TRL 5, having been proven in a laboratory environment. It is progressing through planned validation phases, with a roadmap leading to full industrial deployment at TRL 9 within 18 months. The development plan includes proof-of-concept adaptation, blind validation with real production batches, and scale-up for multi-line deployment.