Integrated model for studying and controlling bovine mastitis using in vivo trials
Agrosavia is developing an in vivo model to study and control bovine mastitis during the dry period using pathogenic field isolates. This project aims to enhance prevention, monitoring, and management strategies for mastitis, leveraging Colombia's unique geographic diversity.
Overview
Agrosavia is pioneering a comprehensive in vivo model to study bovine mastitis during the dry period, using pathogenic field isolates in Holstein Friesian and Blanco Orejinegro cows. This project aims to develop innovative strategies for the prevention, monitoring, and management of mastitis, a significant issue in bovine health and production. With Colombia's diverse climate and geography, this research holds international relevance and potential applications across various farming environments.
Technical specifications
The research involves the use of germplasm banks containing microorganisms from clinical mastitis cases. Initial trials will determine the most effective pathogenic strains and inoculation methods, such as deep injection or inoculated sealing plugs. The model will be applied in controlled trials with 10 animals across two environments, testing two distinct control options. Monitoring will include conventional microbiology, mammary microbiome analysis, clinical signs, paraclinical and immune responses, and qPCR diagnostics, providing a comprehensive understanding of the infection and control mechanisms.
Technology readiness level
This innovative approach is at Technology Readiness Level 5, indicating that the concept has been validated in relevant environments through controlled trials. Further development and validation will continue to refine the model and control strategies for broader application in the field.
About Agrosavia
AGROSAVIA is Colombia’s public agricultural R&D corporation near Bogotá, operating a nationwide network of research centers and experimental farms. Co-located labs, greenhouses, pilot plots and living collections—including national germplasm banks—enable rapid prototyping and access to diverse genetic resources. An outreach and innovation network links companies and producer groups to multi-site trials and farmer engagement across varied agroecological zones. Research is backed by the Government of Colombia—principally the Ministry of Agriculture and Rural Development—with competitive national and international funding, and a technology transfer function to structure collaboration and IP.
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