Intercalated microbubble for enhancing probiotic stability in acidic beverages
Innovative intercalated microbubble technology improves the stability and bioactivity of probiotics in acidic beverages. Uses a multi-shell nanocoating structure to protect probiotics from harsh conditions like acid, heat, and bile salts.
Overview
The intercalated microbubble technology offers a novel solution for enhancing the stability and bioactivity of probiotics in acidic beverages. This innovative approach utilizes a multi-shell layer structure to effectively shield probiotics from harsh environmental conditions, such as low pH levels, heat, and bile salts. By providing a robust protective barrier, this technology significantly improves the survival rate of probiotics, ensuring their efficacy over extended storage periods.
Technical specifications
The technology comprises a sophisticated three-layer structure:
- Inner shell layer: A nanocoating made of food biomolecules like proteins or polysaccharides that encapsulates probiotics, offering initial protection.
- Middle layer: Composed of hydrophobic molecules such as zein, creating a waterproof barrier.
- Outer shell layer: An intercalated structure of food carboxylated polysaccharides with metal oxides that blocks gas molecule penetration. This design ensures the integrity and functionality of probiotics in challenging environments, making it ideal for application in sour beverages.
Technology readiness level
Currently, this technology is at TRL 3, with experimental proof of concept demonstrated through various tests. Future evaluations will focus on long-term stability in beverages, sensory effects, and environmental impact on probiotic survival. The research team seeks partnerships for equipment, probiotic strains, and financial support to advance development.
About China Agricultural University
China Agricultural University is a leading public research university in Beijing that specializes in agriculture while drawing on broad cross‑disciplinary capacity. Industry collaborates through experimental farms and field stations for piloting and validation, and through a university science park that hosts a platform for showcasing and transacting research outputs. The university’s Science and Technology Backyard model embeds researchers in rural cooperatives, accelerating adoption and supply‑chain impact. Research is supported by competitive funding from national agencies such as the National Natural Science Foundation of China and the Ministry of Science and Technology, along with Ministry of Education and regional programs. A dedicated technology transfer office advances IP protection, licensing, and partnerships within the science park.
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