Lactobacillus encapsulation for low ph beverages using spinning disk reactor
Innovative encapsulation method using spinning disk reactor to create stable, high molecular weight polylactic acid nanoparticles for probiotic delivery in low pH beverages. Seeking partners for probiotic supply and regulatory consultancy.
Overview
This technology offers an advanced method for encapsulating Lactobacillus probiotics in polylactic acid nanoparticles using a spinning disk reactor. The method is designed to enhance the stability and delivery of probiotics in low pH beverages, addressing the challenge of maintaining probiotic viability in acidic environments. The encapsulation process leverages high shear forces to produce uniform, stable nanoparticles that can effectively protect and deliver active probiotics.
Technical specifications
Key features:
- Utilizes a spinning disk reactor to generate high shear forces for nanoparticle creation
- Produces uniform, high molecular weight polylactic acid nanoparticles
- Designed to encapsulate Lactobacillus probiotics for enhanced stability in low pH environments
- Future validation includes testing various rotational speeds, pH levels, temperatures, and pressures
- Stability studies in line with ICH guidelines for pharmaceuticals
Technology readiness level
Currently at Technology Readiness Level 4, this technology has been validated in a laboratory setting with controlled experiments. Future development will focus on optimizing conditions for encapsulation efficiency and stability in commercial applications. The project seeks partners for supplying probiotics, providing regulatory consultancy, and securing funding for further development.
About École Polytechnique de Montréal
Polytechnique Montréal is a large public engineering school affiliated with Université de Montréal, combining rigorous academic programs with applied research at scale. Industry engagement is built into the model through structured co-op and internship pathways, on‑campus collaboration spaces, and longstanding partnerships with regional and global firms. Its location within a major research university ecosystem—and near teaching hospitals and startup hubs—helps companies move from prototype to validation and deployment. Research is supported by competitive federal funding from agencies such as NSERC and the Canada Foundation for Innovation, alongside provincial and industry investment. A dedicated technology transfer office assists with IP strategy, licensing, and startup formation, with streamlined agreements for sponsored research.
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