Lactose-based hydrogels for protein stabilization
Introducing a scalable, green technology utilizing lactose-based hydrogels to stabilize proteins. This solution harnesses lactose, a cheese manufacturing byproduct, forming a protective matrix that enhances protein thermostability and controlled release.
Overview
Cornell University presents an innovative approach to protein stabilization using lactose-based hydrogels. This scalable technology immobilizes proteins within a hydrogel matrix derived from lactose methacrylate, offering enhanced thermostability and controlled release. By leveraging lactose, a byproduct of cheese production, this method provides a sustainable and cost-effective alternative to traditional sugars like trehalose. The hydrogels form a glassy matrix that limits protein degradation and maintains structural integrity, making them ideal for pharmaceutical and industrial applications.
Technical specifications
- Hydrogel composition: Synthesized from lactose methacrylate via photoirradiation.
- Protein stabilization: Immobilizes globular proteins, enhancing thermostability by reducing conformational changes during thermal stress.
- Tunable properties: Allows for controlled protein release, adaptable for varying protein sizes, charges, and hydrophobicity.
- Comparative advantage: Offers a glass transition temperature close to trehalose (lactose~101°C, trehalose ~115°C) for effective stabilization.
Technology readiness level
Currently at TRL 3, this technology has been demonstrated in a laboratory setting with ongoing validation processes. The next steps involve immobilizing various proteins to showcase the hydrogel's broad applicability and its effectiveness in enhancing protein stability and release profiles.
About Cornell University
Cornell University is a comprehensive private, land-grant research university with campuses in Ithaca and New York City, combining significant scale with cross-disciplinary breadth. Industry connects through open-access user facilities and prototyping labs, pilot-scale testbeds, and a research and technology park that provide pathways from discovery to demonstration. A statewide extension network and integration with a major hospital system enable real-world deployment, while a graduate campus embedded in New York City’s tech corridor provides direct access to startups, venture investors, and corporate R&D teams. Research is supported by competitive federal funding from agencies such as the National Science Foundation, National Institutes of Health, the Department of Energy, and the U.S. Department of Agriculture. A dedicated technology transfer office streamlines IP management, licensing, startup formation, and corporate partnerships across campuses.
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