Long-acting injectable technologies
We will develop and optimize injectable long-acting formulations for biologic medicines using a stepwise formulation, characterization, and validation workflow. Formulations will be screened for protein loading, viscosity, syringeability, gelation behavior, mechanical stability, and sustained release. Key performance targets include high biologic loading above 100 to 200 mg/mL, injectability through small-gauge needles such as 25G, and controlled release over weeks to months after a single administration.
Validation will include in vitro release testing, antibody stability assays, binding or activity retention studies, rheological characterization, and accelerated stability testing. Lead formulations will then be evaluated in preclinical pharmacokinetic studies to measure sustained systemic exposure, bioavailability, and safety after subcutaneous injection. Early platform data have shown promising injectability, rapid depot formation, and up to multi-fold improvements in drug exposure compared with conventional bolus injection, supporting further development toward sponsored translational studies.
About University of the Pacific
University of the Pacific is a private, comprehensive university with three campuses across Northern California that blend undergraduate, graduate, and professional education. Industry engagement is built into the model: the School of Engineering and Computer Science runs a paid 6–8‑month cooperative education program with employers, while the San Francisco and Sacramento campuses offer hands‑on clinical and policy environments for real‑world testing and translation. Corporate collaborations are supported by an Office of Research and Sponsored Programs that streamlines proposals, agreements, and compliance; the Dugoni School’s Center for Innovation and Translation works with companies to evaluate and scale technologies across university clinics. Faculty secure competitive federal and state support, including awards from NIH and NSF. The tri‑campus footprint links talent pipelines, patients, and policymakers in one of the nation’s most dynamic innovation regions.
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