Low-cost reusable microdroplet generator for probiotic encapsulation
Innovative microdroplet generation system for encapsulating probiotics using low-cost materials, achieving high production rates. The system supports various gel matrices and ensures probiotic viability, addressing industrial scale-up challenges.
Overview
This innovative microdroplet generation system offers a cost-effective and efficient solution for encapsulating probiotics. By leveraging industrial-scale texture manufacturing, the technology produces microdroplets at a high rate using low-cost materials. The system integrates a cleanable, reusable housing with temperature control, capable of generating 100pL droplets at approximately 600mL/hr. The system's ability to multiplex further increases production capacity, making it suitable for industrial applications.
Technical specifications
- Microdroplet size: 100 picoliters
- Production rate: ~600mL/hr, with potential for tripling via multiplexing
- Materials: Low-cost, easily cleanable components
- Temperature control: Integrated within the housing system
- Encapsulation matrix compatibility: Supports various gel matrices
- Application: Enhances probiotic viability in storage and gastrointestinal conditions
Technology readiness level
This technology is at Technology Readiness Level 3. It has demonstrated the ability to generate hydrogel microdroplets and control droplet parameters in laboratory settings. Plans are underway to optimize formulations and build a larger-scale production system as proof-of-concept.
About University of Maine
The University of Maine is a comprehensive public research university and the state’s flagship, coupling broad academic depth with an applied, industry‑oriented culture. On campus, companies access large‑scale prototyping facilities, pilot‑scale lines, and specialized test tanks that move concepts toward deployable systems. A statewide Cooperative Extension and field sites connect R&D teams to real‑world conditions across Maine’s coastal, forested, and cold‑weather settings, while industry liaisons streamline sponsored research. Funding comes from competitive federal sources such as the National Science Foundation, Department of Energy, U.S. Department of Agriculture, and the National Oceanic and Atmospheric Administration, while a centralized tech transfer office supports IP, licensing, SBIR/STTR, and startup formation.
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