Measurements of mucociliary clearance in the human lung

We have experience in measuring mucus clearance rate in the human lung using an aerosol-based nuclear imaging technique. These measurements have been used as supportive evidence in the development of medications that promote mucus hydration or mucus clearance. The technique provides measurements of mucociliary or cough clearance rate. The duration of the measurement allows for some differentiation between small and large airway clearance. These techniques were used in the development of corrector-potentiator therapy in cystic fibrosis. We have also applied these techniques in asthma, COPD, muscular dystrophy, and ciliopathies and also to test the efficacy of devices that promote clearance. The technique can be applied in children or adults. Our center is one of a small number of US centers that are experienced with the technique.