Melt-in-mouth pediatric tablets with real-time NIR monitoring
Innovative pediatric tablets designed to melt in the mouth without water, enhancing compliance and dosing accuracy. Utilizes GRAS excipients and real-time NIR spectroscopy for content uniformity, making it scalable and cost-effective for children aged 2-12.
Overview
The melt-in-mouth pediatric tablets are designed to enhance compliance and dosing accuracy for children aged 2-12. These tablets dissolve rapidly in the mouth within 10 seconds, eliminating the need for water and providing a convenient dosage form for caregivers and children. This solution uses Generally Recognized as Safe (GRAS) listed excipients and superdisintegrants to achieve fast disintegration and improved palatability. The integration of real-time near-infrared (NIR) spectroscopy ensures content uniformity, allowing precise low-dose delivery and reducing the risk of dosing errors.
Technical specifications
- Rapid disintegration: Tablets melt in less than 10 seconds using GRAS excipients.
- Real-time monitoring: NIR spectroscopy is employed immediately after compression to verify content uniformity.
- Scalable production: Utilizes standard tablet presses for cost-effective manufacturing.
- Child-friendly design: Enhances convenience and compliance by eliminating the need for water.
- Application range: Suitable for children aged 2-12, targeting common pediatric medications.
Technology readiness level
The technology is at a Technology Readiness Level (TRL) of 4, indicating that it has been validated in a laboratory environment. The next steps involve pre-formulation trials, formulation optimization, and pilot-scale batch production for further development and market readiness.
About Rutgers University
Rutgers University is a comprehensive public research university and New Jersey’s flagship, spanning campuses in New Brunswick–Piscataway, Newark, and Camden. For industry, it offers an integrated clinical and biomedical enterprise through its health system, a statewide extension network for field deployment, and campus-based incubators and pilot-scale facilities that enable prototyping and scale-up. Companies engage through sponsored research, shared core facilities, professional education, and flexible partnership models supported by corporate engagement teams. Research is supported by competitive federal funding from agencies such as NIH, NSF, DOE, and USDA. A dedicated technology transfer office manages IP, licensing, material transfer, and startup formation, providing clear pathways from lab discovery to market.
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