Metabogenomics pipeline for natural product discovery and scaling
Battelle's metabogenomics pipeline integrates genomics, bioinformatics, and strain engineering to discover and scale natural products. This advanced approach supports microbial onboarding, characterization, and pilot-scale production, targeting bioactive compounds within Proteobacterial hosts.
Overview
Battelle's cutting-edge metabogenomics pipeline offers a robust solution for discovering and scaling natural products. By combining genomic, bioinformatic, and strain engineering technologies, this pipeline identifies and evaluates bioactive compounds within Proteobacterial hosts. The approach supports microbial onboarding and characterization to pinpoint synthesis pathways and conditions for natural product creation. With Battelle's expertise in bioinformatics and microbial engineering, this solution is designed to transition promising natural products to pilot-scale production efficiently.
Technical specifications
Key features:
- Utilizes whole genome sequencing, transcriptomics, and untargeted metabolomics for comprehensive microbial characterization.
- Employs high-throughput automation and microbial culturing to assay thousands of conditions for metabolite identification.
- Integrates computational pipelines for genomics, transcriptomics, and metabolomics to synthesize data and identify biosynthetic gene clusters.
- Supports bench-scale production and evaluation of natural products in microbial systems, producing milligram quantities for efficacy assessment.
Technology readiness level
This technology is currently at TRL 4, indicating that it has been validated in a laboratory environment. Further development and pilot-scale production tasks are planned to advance its maturity and applicability.
About Battelle Memorial Institute
Battelle Memorial Institute is an independent, nonprofit applied research and technology organization headquartered in Columbus, Ohio, operating at scale with multidisciplinary teams and facilities across the U.S. Industry engages through contract R&D performed in collaborative laboratories, pilot‑scale testbeds, and secure environments that meet regulatory, safety, and quality needs. Experience managing U.S. national laboratories and complex partnerships equips collaborators for mission‑critical development and field deployment. Work is supported by competitive federal funding from agencies such as the U.S. Department of Energy, Department of Defense, National Institutes of Health, and Environmental Protection Agency, alongside private‑sector contracts, with a dedicated technology transfer office enabling IP, licensing, and spinouts.
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