Microencapsulated probiotics for low ph food and beverage applications

Overview

Nulixir presents an innovative encapsulation technology, the Nusome™, designed to significantly improve the stability and survival rates of probiotics in low pH food and beverage applications. By encasing fragile probiotics in a protective Nusome shell, this technology not only enhances the stability of probiotics against environmental stressors such as moisture, air, and heat but also ensures their safe passage through the gastrointestinal tract. Additionally, the surface of Nusomes can be functionalized to enable targeted release, thereby enhancing the efficacy of probiotic products.

Technical specifications

• Encapsulation Technology: Nusome™ is analogous to a solid-state Liposome, mirroring the protective qualities of a probiotic spore shell.
• Protection Features: Provides stability against moisture, UV light, oxygen, and low pH environments, ensuring prolonged shelf life.
• Compatibility: Suitable for various formulations including powders and acidified beverages.
• GRAS Materials: Made with generally recognized as safe (GRAS) materials, ensuring safe consumption.
• Customizable Release: Functionalized for targeted release in the gut to enhance bioavailability and efficacy.

Technology readiness level

The Nusome™ technology is currently at Technology Readiness Level 5, indicating that it has been validated in a relevant environment. Future steps include further testing for shelf life stability, slow release, and pH stability, followed by clinical trials to demonstrate efficacy and bioavailability.