Monoclonal antibodies for cow's milk allergen diagnostics and therapy
Innovative monoclonal antibodies targeting specific cow's milk allergen IgE epitopes for sensitive diagnostics and therapy. Offers high specificity and affinity, stable storage, and scalable production.
Overview
Nanchang University presents a breakthrough in allergen-specific diagnostics and immunotherapy using monoclonal antibodies developed from cow's milk allergen-specific IgE epitopes. This platform targets key epitopes in cow's milk allergens, providing high specificity and affinity antibodies for sensitive diagnostics and residue assays. These antibodies are stable for up to six months at 4 °C and hold potential for epitope-specific immunotherapy applications.
Technical specifications
The research involved screening cow's milk allergy (CMA) sera and identifying 21 linear epitopes, leading to 10 core peptides. Immunization of mice and subsequent antibody screening resulted in antibodies with a dissociation constant (KD) of 1.2–8.7 nM, demonstrating >95% specificity. These antibodies are capable of pinpointing allergenic peptides altered by ultra-processing, contributing to both diagnostics and mechanistic immunology.
Technology readiness level
Currently at TRL 4, this technology has been validated at the laboratory scale with plans for further optimization and scale-up. Future validation includes enhancing antibody production consistency, large-scale preparation, purification, and comprehensive quality control testing, ensuring readiness for commercial applications.
About Nanchang University
Nanchang University is a comprehensive public research university in Jiangxi Province with broad academic breadth and a strong applied orientation. Industry partners engage through a university science and technology park recognized as a national high‑tech incubator, state‑level laboratories and engineering centers, and an integrated multi‑hospital system that enables clinical collaboration. Its location in Nanchang—a fast‑growing manufacturing hub—provides access to policy‑backed industrial clusters and a deep supplier base, supporting rapid collaboration with regional manufacturers. Research is backed by competitive national funding, including sustained support from the National Natural Science Foundation of China and programs of the Ministry of Education. A dedicated technology transfer and IP service infrastructure streamlines agreements, licensing, and startup incubation.
delivered to your inbox.