Mucoadhesive ha-g-pnipam nanogel for oral care
A novel mucoadhesive, thermoresponsive nanogel technology for enhanced delivery of oral care actives. Designed to increase retention and bioavailability on gingival and mucosal surfaces, suitable for diverse formulations including gels, serums, and films.
Overview
The HA-g-pNIPAM nanogel represents a cutting-edge advancement in oral care delivery systems. This innovative technology combines hyaluronic acid with poly(N-isopropylacrylamide) to create a mucoadhesive, thermoresponsive nanogel. At room temperature, it exists as a low-viscosity liquid, transforming into a self-assembling nanogel at body temperature. This transformation prolongs contact time on oral surfaces, thereby enhancing the retention and bioavailability of active ingredients and flavors. The technology offers flexibility across different formats such as rinse-off, leave-on, or booster applications, making it a versatile solution for oral care enhancement.
Technical specifications
- Mucoadhesive properties: Enhances retention on mucosal surfaces, providing sustained release of actives.
- Thermoresponsive behavior: Transforms at oral temperature to increase mucosal residence time.
- Compatibility: Can carry a variety of actives like curcumin, Centella extract, CBD, and more.
- Tunable formats: Adaptable to rinse-off gels, leave-on serums, and more.
- Clinical validation: Supported by a published clinical trial showing improved oral soft-tissue conditions.
Technology readiness level
This technology is at TRL 6, with successful trials demonstrating its efficacy and safety. It is ready for pilot engagements and collaborative studies to further explore its potential in delivering oral care actives.
About MOMENT OF YOUTH CO., LTD.
M.O.Y. (Moment of Youth) is a science-driven skincare brand founded in 2024 that specializes in developing activity-specific products for outdoor enthusiasts. The company focuses on addressing the skin stressors caused by diverse environments, such as high-altitude sun, saltwater, pollution, and cold air. Their products are formulated in-house using advanced cosmetic technology, including their proprietary HyaSphereX delivery system—a 3D nanogel made from hyaluronic acid that facilitates deeper skin absorption and barrier repair. By utilizing bio-based, vegan, and cruelty-free ingredients, the company aims to provide high-performance solutions that protect and restore skin for people engaged in active, outdoor lifestyles.
For customers, M.O.Y. solves the problem of traditional skincare failing to perform under rigorous, real-world outdoor conditions. By creating targeted formulations for specific environments—such as water, urban settings, and extreme climates—the brand supports athletes, adventurers, and active individuals in maintaining skin health despite environmental exposure. The company emphasizes rigorous R&D, clinical backing, and sustainable production methods to ensure their products are both effective and environmentally responsible. M.O.Y. is headquartered in Huntington Beach, California, and engages its community through initiatives like its Co-Creator Campaign and participation in athletic events.
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