Mucoadhesive strip for sustained gingival delivery of anti-inflammatory actives
A novel mucoadhesive bilayer strip designed for overnight gingival application, delivering curcumin and omega-3 fatty acids. It extends contact time beyond traditional rinses and gels, targeting inflammation with a sustained-release mechanism. The strip's formulation can be customized to include partner actives.
Overview
The mucoadhesive strip represents a breakthrough in gingival care, offering a sustained, overnight delivery system for anti-inflammatory agents. Unlike traditional rinses and gels, this bilayer strip adheres securely to the gingiva, ensuring prolonged exposure to its active ingredients—curcumin and omega-3 fatty acids. These compounds work synergistically to suppress inflammatory cell proliferation, addressing gingival inflammation effectively.
Technical specifications
- Bilayer Design: Features a mucoadhesive layer for secure attachment and an active layer for delivering therapeutic agents.
- Active Ingredients: Curcumin with omega-3 fatty acids, proven to act synergistically on inflammatory cells.
- Customizable Formulation: Capable of incorporating partner-specific actives like CPC or stannous fluoride under appropriate IP terms.
- Retention: Demonstrated retention beyond 1 hour; targeting 4-hour and overnight retention.
- Compatibility: Nanofiber material used is biocompatible and safe for oral use.
Technology readiness level
Currently at TRL 4, the strip has shown promising results in initial retention tests and in vitro studies. Future phases aim to validate overnight retention and clinical efficacy through structured trials and partner collaborations.
About University of Ljubljana
The University of Ljubljana is a comprehensive public research university and Slovenia’s largest, anchored in the capital with extensive faculty laboratories and clinical, cultural, and technical assets. Companies engage through a central Knowledge Transfer Office that brokers collaborative R&D, IP licensing, and spin‑out pathways, complemented by the Ljubljana University Incubator for venture creation; the city’s technology park adds a dense startup and scale‑up community. Clinical translation benefits from integration with the University Medical Centre Ljubljana, enabling access to hospital‑based research and patient cohorts. Research is supported by competitive European programs and Slovenia’s national research and innovation agency (ARIS). Clearly defined commercialization routes—technology offers, industry matchmaking, and spin‑outs—help partners move from proof‑of‑concept to market.
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