Multi-targeted bioactive-loaded topical nanoemulsion for neuropathic pain relief
An advanced nanoemulsion delivering targeted, nonprescription relief for neuropathic pain using multi-active ingredients like capsaicin, CBD, and menthol for enhanced efficacy and skin penetration.
Overview
This innovative topical nanoemulsion is designed to provide targeted relief for neuropathic pain through a multi-active approach. By combining capsaicin, menthol, peppermint oil, cannabidiol (CBD), palmitoylethanolamide (PEA), and alpha-lipoic acid, the formulation offers a comprehensive solution that addresses pain via several synergistic mechanisms. These include sensory nerve desensitization, cooling modulation, endocannabinoid system regulation, and antioxidant neuroprotection, delivered in a consumer-friendly, over-the-counter format.
Technical specifications
- Capsaicin: Desensitizes TRPV1 pain receptors to reduce pain sensation.
- Menthol and peppermint oil: Provide immediate cooling relief through TRPM8 modulation.
- Cannabidiol (CBD) and palmitoylethanolamide (PEA): Work to calm nerve inflammation and modulate the endocannabinoid system.
- Alpha-lipoic acid: Offers neuroprotection through its antioxidant properties.
- Nanoemulsion delivery system: Stabilized with hydrolyzed collagen and hyaluronic acid, enhanced with ceramides and phytosphingosine for improved skin penetration and barrier restoration.
Technology readiness level
Currently at Technology Readiness Level 3, this nanoemulsion has undergone formulation and pre-clinical validation stages. Future validation plans include scaling up production, conducting safety testing, and creating prototypes for further evaluation.
About Texas A&M University, College Station
Texas A&M University in College Station is a comprehensive public research university and the flagship of The Texas A&M University System, combining broad academic strengths with a strong applied‑research culture. Industry collaborates on the Texas A&M‑RELLIS campus—an integrated education, research and testing environment that supports large‑scale experimentation and proving grounds—and through the Texas A&M Transportation Institute’s facilities in Bryan‑College Station. A statewide extension network connects university expertise to companies and communities across all Texas counties, enabling rapid piloting and deployment. Research is supported by competitive federal funding from agencies such as NSF, NIH, DOE, USDA and DoD, alongside state and industry sponsorship. Texas A&M Innovation provides IP management, licensing and commercialization pathways across the system.
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