Multiplexed mycotoxin analysis using UPC2 chromatography and mass spectrometry
A rapid, cost-efficient, and environmentally friendly strategy for multiplexed mycotoxin analysis using UPC2 chromatography combined with PDA and single quadrupole analyzers. Suitable for complex matrices, this approach allows sensitive quantification of known and unknown mycotoxins.
Overview
This innovative solution leverages UPC2 chromatography combined with photodiode-array (PDA) and single quadrupole (QDA) mass spectrometry for the efficient analysis of mycotoxins. Mycotoxins, hazardous compounds produced by fungi, can contaminate food supplies, posing significant risks to human and animal health. Our approach uses green, non-toxic compressed liquid CO2 as the primary mobile phase, making it environmentally friendly. This method allows for the sensitive and rapid quantification of both known and unknown mycotoxins from complex matrices, offering a comprehensive strategy for food safety monitoring.
Technical specifications
- UPC2 Chromatography: Utilizes convergence chromatography with compressed liquid CO2 for the separation of complex natural product mixtures.
- Detection System: Combines PDA and QDA analyzers for robust quantification.
- Analyte Coverage: Capable of detecting mycotoxins such as aflatoxins, ochratoxin A, and others in cereals and related products.
- Efficiency: The method is cost-effective due to its rapid analysis time and environmentally benign reagents.
- Flexibility: Supports both positive and negative ionization modes for comprehensive mycotoxin detection.
Technology readiness level
The technology is currently at TRL 4, indicating that it has been validated in a laboratory setting. Future validation efforts will focus on method development, testing with complex matrices, and formal validation according to industry standards, in collaboration with diagnostics partners.
About Cinvestav
Cinvestav is a Mexican public research center and graduate‑only institute with multiple research units nationwide and a scope that spans fundamental discovery through translation. Industry engagement is coordinated through liaison offices across its units, enabling sponsored research, contract testing, and access to shared instrumentation via standardized agreements. Its national footprint places teams in Mexico City, Guadalajara, Monterrey, Mérida and other metros along key manufacturing corridors, supporting on‑site collaboration, talent pipelines, and rapid technology validation. Research is backed by Mexico’s national science and technology council as well as competitive federal and international programs. A dedicated technology transfer office supports IP strategy, licensing, startup formation, and confidentiality frameworks for corporate collaborations.
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