NADES technology for enhanced bioavailability and stability of micronutrients
NADES technology offers a novel platform to enhance the bioavailability and stability of micronutrients, using non-toxic, biodegradable systems. Ideal for nutraceuticals and pharmaceuticals, it improves solubility and permeability of active ingredients, enhancing delivery in supplements.
Overview
Natural Deep Eutectic Systems (NADES) present an innovative platform for improving the bioavailability and stability of micronutrients in supplements. These systems are formed by mixing natural compounds in specific molar ratios, resulting in a liquid that is non-toxic, biocompatible, and biodegradable. This technology offers significant advantages for nutraceuticals and pharmaceuticals by enhancing the solubility and permeability of active ingredients, thereby improving their delivery and efficacy in oral supplements like gummies, gels, and capsules.
Technical specifications
- Key Features:
- Over 600 tailored NADES for specific micronutrients and bioactive compounds.
- Ability to solubilize poorly water-soluble molecules and extract high-value components with high yields.
- Stabilizes active ingredients for over 6 months without loss of bioactivity.
- Utilizes Hansen Solubility Parameters to predict compatibility with micronutrients.
- Applications:
- Enhancing bioavailability and solubility of micronutrients in oral supplements.
- Improving stability in nutraceutical and pharmaceutical formulations.
- Validation Procedures:
- Screening and compatibility assessments using in vitro and in vivo models.
- Solubility, homogeneity, and permeability evaluations through advanced techniques like HPLC and polarized light microscopy.
- Stability testing under various conditions to ensure long-term efficacy.
Technology readiness level
The technology is currently at TRL 3, indicating that it has been experimentally demonstrated and is in the early stages of development. Further validation steps include compatibility screening, cytotoxicity and ecotoxicity assessments, and incorporation into commercial supplement formulations.
About Universidade NOVA de Lisboa
NOVA University Lisbon is a comprehensive public research institution spanning multiple campuses across the Lisbon metro area, combining selective excellence with an applied, collaborative ethos. Industry engages through co‑located laboratories at FCT NOVA and a science and technology park adjacent to the Caparica campus, alongside structured corporate partnership programs. Clinical translation is enabled by NOVA Medical School’s integration with Lisbon’s hospital network and clinical academic consortia, providing access to patient populations and real‑world settings. Research is supported by competitive European and Portuguese national funding, including Horizon Europe and the Foundation for Science and Technology, complemented by industry‑sponsored work. University‑wide innovation offices and school‑level TTOs provide IP, licensing, and startup support as a clear entry point for corporate R&D.
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