Nano-neuromedicine for Alzheimer's disease: Advanced drug delivery system
This nano-neuromedicine technology leverages nanocarrier systems to enhance drug delivery across the blood-brain barrier, specifically targeting Alzheimer's disease. Utilizing nanoconjugates like curcumin with nanoparticles, it offers improved drug efficacy and reduced resistance.
Overview
Nano-neuromedicine represents a breakthrough in the treatment of Alzheimer's disease by utilizing advanced nanocarrier-based drug delivery systems. Traditional treatments often fail due to poor solubility, low bioavailability, and challenges in crossing the blood-brain barrier (BBB). This innovative approach leverages nanotechnology to overcome these limitations, offering faster absorption, targeted interactions, and controlled release of therapeutic agents, thus promising more effective treatment outcomes.
Technical specifications
The core of this solution involves the use of curcumin nanoconjugates, which are designed to efficiently cross the BBB. These conjugates are prepared with metal gold nanoparticles, metal oxide nanoparticles, and carbon dots (C-Dots), all of which are less than 20 nm in size. The delivery mechanism capitalizes on endocytosis via the Low Density Lipoprotein (LDL) receptor of endothelial cells. This enables targeted delivery of drugs directly to the brain, addressing the major challenge of drug transport in neurodegenerative diseases.
Technology readiness level
Currently at Technology Readiness Level 2, this technology is in the early stages of concept validation. Research is focused on synthesizing biocompatible carbon dots as therapeutic agents, which can easily pass through the BBB with a drug molecule attached, promising significant advancements in Alzheimer's treatment.
About University of Agricultural Sciences
University of Agricultural Sciences, Bengaluru, is a public agricultural university serving Karnataka through campus laboratories and a network of research farms and teaching units. Industry partners leverage co‑located facilities, demonstration plots, and access to multi‑location on‑farm trials across distinct agro‑climatic zones. A robust extension system links researchers with growers and agribusiness for rapid feedback, field validation, and scale‑up. Research is supported by Indian national agencies such as ICAR, DST, and DBT, alongside state and industry funding. Dedicated IP and licensing services assist with protection, agreements, and startup formation.
Inquire about this partnering listing
Industry applications
delivered to your inbox.