Natural fungicidal solutions enhancing synthetic drug efficacy
This research identifies plant-derived extracts with fungicidal potential against Candida species, aiming to enhance synthetic drug efficacy while offering a natural alternative for vaginal fungal infections.
Overview
Natcrom Soluções Sustentáveis presents a novel approach to treating vaginal fungal infections, such as candidiasis, by utilizing plant-derived extracts with proven fungicidal potential. This solution aligns with consumer trends demanding natural and clean-label health products. By enhancing the efficacy of existing synthetic drugs like fluconazole, these natural extracts offer a promising alternative that reduces chemical additives and promotes sustainable treatment options.
Technical specifications
Key features:
- Plant extracts tested in vitro against C. albicans and C. parapsilosis strains
- Minimum inhibitory concentration (MIC) values greater than 3.9 µg/mL observed
- Synergistic activity with fluconazole demonstrated via checkerboard assay
- Potential to reduce synthetic drug dosage, promoting eco-friendly solutions
Technology readiness level
The research is at Technology Readiness Level 3, with in vitro validation completed. Future validation will focus on identifying active compounds, determining their fungicidal or fungistatic nature, and developing formulations to ensure efficacy and safety in alternative infection models.
About Natcrom Soluções Sustentáveis
Natcrom Soluções Sustentáveis is a deep tech startup based in Araraquara, Brazil, specializing in the production of sustainable botanical ingredients derived from agro-industrial byproducts and Brazilian biodiversity. Founded in 2020 by researchers with backgrounds in chemistry and biotechnology, the company leverages advanced extraction, separation, and purification techniques—including various forms of chromatography and spectroscopy—to isolate bioactive molecules such as antioxidants and antimicrobials. Their work is grounded in the principles of green chemistry and circular economy, focusing on transforming waste materials into high-value natural ingredients while ensuring standardized quality and chemical identity.
The company provides essential solutions for clients seeking high-performance, clean-label alternatives to synthetic additives. By offering comprehensive analytical services—such as metabolomics, structural characterization, and method validation—Natcrom assists partners in developing and validating natural products. Their research-driven approach, supported by academic expertise and investments from initiatives like PIPE-FAPESP, allows them to provide transparent, scientifically verified ingredients. This enables customers, particularly in the food, cosmetic, and pharmaceutical industries, to integrate sustainable, effective botanical compounds into their own product formulations, meeting the growing market demand for environmentally friendly and reliable natural inputs.
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