National Centre for Scientific Research "Demokritos"

Natural mosquito anosmia-inducing compounds

Technology
In development
University

Innovative natural compounds that induce anosmia in mosquitoes by antagonizing the ORco receptor, preventing host recognition. These compounds offer a non-invasive solution to reduce mosquito bites, leveraging AI-enhanced screening for discovery.

Overview

The development of natural mosquito anosmia-inducing compounds provides a groundbreaking approach to mosquito control by targeting the odor receptor co-receptor, ORco. These compounds act as antagonists, blocking the activation of odor receptors, which results in anosmia-like effects. This effectively prevents mosquitoes from recognizing and locating their hosts, reducing the incidence of mosquito bites without the need for direct application on humans or animals.

Technical specifications

Key features:

  • Utilizes volatile organic compounds (VOCs) of natural origin as ORco antagonists
  • Causes inactivation of mosquito odor receptors, inducing anosmia
  • AI-enhanced cell-based screening platform for efficient discovery of effective VOCs
  • Designed to work across various mosquito species, offering broad applicability
Technology readiness level

This technology is at Technology Readiness Level 6, indicating that the system or its components have been demonstrated in a relevant environment, and further validation is underway through AI-enhanced pre-screening algorithms to streamline discovery processes.

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