Natural mosquito repellents using thymol and geraniol
Developing safe and eco-friendly mosquito repellents using thymol and geraniol, leveraging computational simulations to target mosquito-specific proteins and reduce toxicity compared to synthetic repellents.
Overview
This innovative research focuses on developing natural mosquito repellents using thymol and geraniol, targeting Aedes aegypti mosquitoes that transmit diseases like dengue and Zika. By focusing on mosquito-specific proteins, this solution aims to disrupt vital functions, offering a safer alternative to synthetic repellents. The goal is to create effective outdoor formulations that are eco-friendly and minimize health risks.
Technical specifications
- Utilizes in-silico computational simulations to model binding interactions between thymol, geraniol, and key mosquito proteins.
- Targets mosquito-specific proteins such as voltage-gated sodium channels and enzymes like GST to hinder mosquito functions.
- Employs machine learning to screen libraries of natural compounds, identifying potential repellent candidates based on binding properties.
- Future steps include wet lab validation with cytotoxicity and mosquito repellency assays to confirm effectiveness and safety.
Technology readiness level
The project is currently at Technology Readiness Level 3, with computational predictions completed and wet lab validation pending. This stage indicates that analytical and experimental critical function and/or characteristic proof of concept are being conducted.
About R.V. College of Engineering
RV College of Engineering (RVCE) is an autonomous, self‑financing engineering institution in Bengaluru, affiliated to Visvesvaraya Technological University and accredited NAAC A+. It connects to industry through an active Industry Institute Interaction Cell, 150+ MoUs, and co‑located, industry‑sponsored labs and Centers of Excellence that enable joint training, prototyping, and upskilling on campus. Proximity to Bengaluru’s technology cluster supports internships, capstone co‑supervision, and consultancy engagements throughout the year. Research here is supported by competitive national programs and industry, including DRDO/NRB, AICTE, and ISRO collaborations. An IP Coordination Cell, together with incubation resources and a student‑run Entrepreneurship Development Cell, assists with patenting, licensing, and venture formation.
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