Natural polyphenol microcapsules for controlled hydrophobic active delivery
Innovative lignin-based microcapsules for controlled release of hydrophobic actives in cosmetics, pharmaceuticals, and agriculture. Utilizing ultrasonication, these biodegradable capsules offer stability and optimal release profiles.
Overview
This innovative solution involves the development of natural polyphenol microcapsules derived from lignin, a biopolymer sourced from plant biomass waste. These microcapsules are engineered to deliver hydrophobic active ingredients in a controlled manner, suitable for applications in cosmetics, pharmaceuticals, and agriculture. The unique property of lignin, being fully biocompatible and biodegradable, ensures safety and environmental friendliness. The microcapsules are formed through an ultrasonication process, which induces aggregation and cross-linking of lignin molecules for enhanced stability.
Technical specifications
- Ultrasonication Process: Utilizes energy to trigger lignin aggregation and cross-linking, forming stable microcapsules.
- Microcapsule Size: Average diameter of d(50) < 6 μm and d(90) < 15 μm, adjustable based on sonication conditions.
- Biocompatibility: Proven negative for cyto- and genotoxicity, ensuring safety in personal care and cosmetic formulation.
- Applications: Specifically designed for controlled release in cosmetics, pharmaceuticals, and agriculture, optimizing active ingredient effectiveness.
Technology readiness level
The technology is currently at TRL 4, having been validated at a laboratory scale with ongoing efforts for optimization and upscaling. Future work involves process integration and intensification using simulation software to enhance commercial viability.
About National Institute of Chemistry (Kemijski inštitut)
Slovenia’s National Institute of Chemistry (Kemijski inštitut) is a leading public research institute based in Ljubljana, bringing together multidisciplinary teams, advanced infrastructure, and close ties with universities to address industry‑relevant challenges. Industry partners engage through contract research, analytical services, collaborative projects, and access to shared facilities such as high‑field NMR, mass spectrometry, and advanced microscopy. Its location near established pharmaceutical and specialty‑chemical manufacturers in Slovenia and Central Europe supports agile partnering, talent pipelines, and rapid technology validation. Research is supported by competitive European Commission programs and national research funding. A dedicated technology transfer office manages IP, licensing, and spinout support, offering clear pathways from discovery to deployment.
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