Non-invasive optical spectroscopy for blood iron measurement
Introducing a non-invasive optical spectroscopy solution to measure blood iron levels through hemoglobin concentration. This cost-effective method uses diffuse optical spectroscopy, reducing the need for invasive serum iron tests.
Overview
This innovative solution leverages diffuse optical spectroscopy (DOS) to offer a non-invasive and cost-effective method for measuring hemoglobin concentration in the blood, thereby assessing iron levels. Unlike traditional serum iron blood tests, which are invasive and time-consuming, this technology uses near-infrared (NIR) light to penetrate skin and interact with blood vessels, modeling diffuse reflectance to determine iron levels.
Technical specifications
- Utilizes near-infrared spectroscopy (NIRS) to measure optical properties by modeling diffuse reflectance.
- Redesigned optical fiber probe with a source-detector distance (SDD) of up to 4 mm and the capability to collect signals at multiple SDDs.
- Maximum outer diameter of the probe is 10 mm.
- Calibration with optical phantom models recommended for FDA 510(k) premarket approval.
- Future enhancements include a neural network model to analyze diffuse reflectance signals for iron concentration.
Technology readiness level
This technology is currently at a Technology Readiness Level 5, indicating that it has been validated in a relevant environment through the use of optical phantom models. Future development will focus on improving signal sensitivity and further validation through advanced modeling techniques.
About University of Alabama, Huntsville
The University of Alabama in Huntsville is a public research university with a STEM-intensive profile and comprehensive academic breadth. Situated in Huntsville's federal and aerospace corridor, the campus sits alongside Cummings Research Park and near Redstone Arsenal and NASA's Marshall Space Flight Center, enabling close collaboration with contractors, startups, and government labs. Industry engagement is embedded in sponsored research, experiential learning, and internship/co-op pathways, with work often carried out in shared or on-campus facilities near corporate R&D sites. Research is supported by competitive federal funding from NASA, the Department of Defense, and the National Science Foundation. A dedicated technology transfer office advances IP protection, licensing, and new venture formation in concert with the regional innovation ecosystem.
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