Novamin & γ-pga toothpaste for enamel protection and whitening
Introducing a fluoride-free toothpaste combining NovaMin bioactive glass and γ-PGA for effective stain removal and enamel protection. This dual-action formulation supports enamel health and delivers visible whitening by enhancing remineralization and forming a protective barrier.
Overview
This innovative toothpaste combines NovaMin bioactive glass with poly-γ-glutamic acid (γ-PGA) to offer a fluoride-free solution for enamel protection and tooth whitening. NovaMin releases calcium and phosphate ions that precipitate into a hydroxyapatite-like layer, while γ-PGA forms a bioadhesive film enhancing ion retention. This dual-action approach not only aids in stain removal but also provides a protective barrier against demineralization, ensuring stronger, stain-free teeth.
Technical specifications
- NovaMin: A well-established bioactive material functioning as a mild abrasive and mineral source.
- γ-PGA: A naturally derived polypeptide that mimics salivary proteins, forming a stable, bioadhesive film on enamel.
- Stain Removal & Protection: Demonstrated through in vitro demineralisation testing and FTIR spectra. γ-PGA reduces mineral loss by approximately 50% in acid challenge conditions.
- Future Validation: Includes optimizing formulation, stain removal testing, and safety assessments such as Relative Dentin Abrasivity and acid resistance.
Technology readiness level
Currently at TRL 3, this toothpaste formulation is undergoing further validation to optimize its efficacy and safety. A comprehensive 12-month laboratory program is planned to refine the product for market readiness.
About Queen Mary University of London
Queen Mary University of London is a comprehensive public research university within the University of London, serving a large and diverse community across campuses in East and Central London. Integration with a major NHS hospital network provides co‑located clinical and translational facilities and access to trial infrastructure and real‑world datasets. An on‑site innovation ecosystem with wet‑lab and startup space, plus proximity to the City and Tech City, connects researchers to London’s finance and digital industry clusters. Research is supported by competitive funding from UK Research and Innovation councils, the National Institute for Health and Care Research, and leading UK charities. A dedicated technology transfer company manages IP, licensing, consultancy, spinouts, and Knowledge Transfer Partnerships to streamline collaboration.
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