Novel biomarkers for diagnosing cardiac rejection and myocarditis

Overview

This research focuses on the development of novel biomarkers for diagnosing and prognosticating cardiac rejection in heart transplant recipients and heart failure due to myocarditis. Current diagnostic methods lack non-invasive, sensitive, and specific markers, creating a crucial need for better solutions. This project aims to fill that gap by identifying biomarkers that can provide reliable and early detection, thus improving patient management and outcomes.

Technical specifications

The research involves examining proteomic profiles in cardiac tissue samples from patients with conditions like cardiac sarcoidosis and heart transplant recipients. These profiles are analyzed to identify potential biomarkers that could serve as non-invasive diagnostic and prognostic tools. The study utilizes myocardial biopsy and heart explant tissues, which are linked to clinical data, providing a comprehensive dataset for robust biomarker discovery.

Technology readiness level

The current research is at Technology Readiness Level 2, indicating that the concept and application have been formulated, and initial exploration of the biomarkers in cardiac tissue samples is underway. Further validation through research projects focusing on proteomics is planned to advance the development of these biomarkers.