Novel nutritional formulation for telomere stability and healthy aging
A GRAS-safe oral supplement combining Astragalus membranaceus with vitamin D and omega-3 fatty acids, designed to support optimal telomere maintenance and promote healthy aging. Developed through computational screening and in silico ADMET and absorption studies, targeting age-related disease prevention.
Overview
This solution is a novel oral nutritional formulation that combines Astragalus membranaceus extract with vitamin D and omega-3 fatty acids to support telomere maintenance and healthy aging. Telomere length is a key biomarker of cellular aging, and preserving optimal telomere integrity is associated with reduced risk of age-related diseases. The formulation is being designed to be Generally Recognized As Safe (GRAS) and suitable for oral consumption, offering a preventive nutraceutical approach to longevity and cellular health.
Technical specifications
- Active botanical source: Astragalus membranaceus, containing compounds such as cycloastragenols and astragalosides that have been linked to telomere preservation
- Synergistic ingredients: vitamin D and omega-3 fatty acids, included to complement the botanical extract and support cellular maintenance
- Computational screening: active compounds were identified and selected using in silico screening methods
- Formulation development: stability testing and cross-reaction analysis performed for the combined ingredients
- In silico ADMET profiling: absorption, distribution, metabolism, excretion, and toxicity properties evaluated computationally for each component, including oral absorption efficacy
- Safety design: formulation targets GRAS status for oral ingestion in humans
Technology readiness level
The formulation is currently at an early stage of development. Active compounds have been identified through computational screening, and preliminary formulation work and in silico ADMET and absorption studies have been completed. The next planned validation step is an in vitro research program involving cultured human cells, dose-response optimization, and telomere length measurement using quantitative PCR or Southern blot analysis, alongside cell viability and proliferation safety assessments. The technology is not yet validated in vivo or in clinical settings and represents an opportunity for partnership in further preclinical development.
About R.V. College of Engineering
RV College of Engineering (RVCE) is an autonomous, self‑financing engineering institution in Bengaluru, affiliated to Visvesvaraya Technological University and accredited NAAC A+. It connects to industry through an active Industry Institute Interaction Cell, 150+ MoUs, and co‑located, industry‑sponsored labs and Centers of Excellence that enable joint training, prototyping, and upskilling on campus. Proximity to Bengaluru’s technology cluster supports internships, capstone co‑supervision, and consultancy engagements throughout the year. Research here is supported by competitive national programs and industry, including DRDO/NRB, AICTE, and ISRO collaborations. An IP Coordination Cell, together with incubation resources and a student‑run Entrepreneurship Development Cell, assists with patenting, licensing, and venture formation.
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