Nrf2-activating peptide for restoring hair color
A cyclic peptide that activates NRF2 to restore hair color by relieving oxidative block in graying follicles. This mechanism-specific solution targets protein-protein interactions to lower peroxide levels, enabling the restoration of melanin production in hair follicles.
Overview
The NRF2-activating peptide offers a novel approach to restoring natural hair color by targeting oxidative stress within hair follicles. Unlike traditional dyes, this solution leverages the body's own antioxidant defenses by activating NRF2, a key regulator in mitigating oxidative damage. The peptide specifically binds to the KEAP1 Kelch pocket, releasing NRF2 and initiating a cascade that reduces hydrogen peroxide accumulation. This action reactivates tyrosinase, allowing melanin production to resume, ultimately restoring natural hair color and protecting melanocytes from oxidative damage.
Technical specifications
- Mechanism of Action: Targets the KEAP1/NRF2 interaction to activate the NRF2 pathway, reducing oxidative stress.
- Active Molecule: Cyclic peptide designed using a structure-based AI platform, with a potency of ~20 nM.
- Application: Topical, INCI-registerable for cosmetic use in US/EU/Canada.
- Intellectual Property: Composition-of-matter and method-of-use IP filed.
- Validation: Proof-of-concept phase includes melanocyte models and ex-vivo human hair-follicle culture tests.
Technology readiness level
This technology is currently at TRL 3, with ongoing proof-of-concept studies planned to further validate efficacy and durability in pigmentation restoration.
About Biologic AI
Biologic AI is a biotechnology company that utilizes an oncology-grade, structure-based artificial intelligence platform to computationally design novel, patent-protected peptides for skin longevity. Its discovery engine is powered by an orchestrated stack of over 40 computational tools, which are calibrated against experimental ground truth to simulate the entire validation process from target to filed intellectual property in silico, minimizing the need for initial laboratory expenditure.
By prioritizing computational discovery over traditional lab-first screening, the company develops mechanism-specific actives aimed at targeting the root molecular drivers of skin aging. This approach allows Biologic AI to generate a pipeline of proprietary compounds that can either be licensed or utilized to develop science-first, owned brands, offering a novel category of solutions in the skin health and beauty sectors.
delivered to your inbox.