University of the Witwatersrand, Johannesburg

Nusome-p: advanced topical sol for neuropathic pain management

Technology
In development
University

NuSome-P is a bioactive topical solution combining surfactants, neuroactive resins, essential oils, and cannabinoids for effective neuropathic pain relief. This scalable and versatile formulation offers three delivery methods: direct application, transdermal patches, and microneedles.

Overview

NuSome-P is an innovative bioactive topical solution designed to address neuropathic pain effectively. This formulation combines a penetrating surfactant, a neuroactive resin, an essential oil, and a cannabinoid within a polar cosolvent. The unique combination allows for efficient diffusion through the skin layers to target the pain site. NuSome-P is versatile, suitable for direct application as a topical sol, integration into transdermal patches, or as microneedles. It promises a universal delivery platform adaptable to various therapeutic needs.

Technical specifications
  • Formulation components: Bioactive surfactant, neuroactive resin, essential oil, cannabinoid, and polar cosolvent
  • Delivery methods: Topical sol, transdermal patches, silicon-based microneedles
  • Mechanism: Simultaneous colloidal arrangement of surfactant and lipid platforms enables encapsulation and incorporation of bioactives
  • Scalability: Designed for industrial scale-up using commercially available excipients and active ingredients
  • Compatibility: Can be used with conventional polymers and Vac-and-Fill technique for microneedles
Technology readiness level

NuSome-P is at Technology Readiness Level 6, indicating it has been tested in relevant environments and is ready for further validation in vitro, pre-clinical, and in vivo settings. The solution is prepared for IP disclosure, assignment, and licensing, with immediate availability for collaboration and testing.

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