Oral microbiome transplantation for caries and periodontal disease
Oral Microbiome Transplantation (OMT) is a pioneering platform designed to reprogram the oral microbiome by introducing healthy microbial communities to prevent or remediate oral diseases like caries and periodontal disease, using 3D-printed bioreactors for manufacturing.
Overview
Oral Microbiome Transplantation (OMT) presents a groundbreaking approach to oral health by reprogramming the oral microbiome. Unlike traditional methods that focus on eliminating harmful microbes, OMT introduces beneficial microbial communities derived from ultra-healthy donors. This innovative therapy utilizes 3D-printed artificial mouth bioreactors for precise manufacturing control. The process involves applying a microbial-laden food-based hydrogel to the teeth, which has shown promising results in pre-clinical trials, including blocking severe cavities and mitigating bone loss associated with periodontal disease.
Technical specifications
Key Features:
- Utilizes 3D-printed bioreactors for controlled manufacturing of microbial communities.
- Employs a food-based hydrogel for effective delivery of microbes to tooth surfaces.
- Demonstrated ability to prevent cavities and reduce periodontal disease symptoms in animal models.
- Focuses on replacing disease-associated microbes with health-promoting communities to create protective biofilms.
Technology readiness level
Current development stands at Technology Readiness Level 5, indicating that the technology has been validated in relevant environments, primarily through pre-clinical trials with animal models. Future plans involve testing in companion animals to further validate efficacy and safety in real-world clinical settings.
About Microversal LLC
Microversal LLC is a biotechnology company focused on developing oral microbiome treatments to prevent dental disease. The company has created a proprietary technology, the Oral Microbiome Transplant (OMT), which involves collecting, studying, and curating beneficial bacteria from donors with naturally perfect oral health. By using an artificial mouth model for research and safety testing, the company aims to introduce these healthy microbes into the mouths of patients, displacing harmful bacteria that contribute to cavities and other dental issues. This research is supported by a team of dental and microbiome experts, including PhDs and researchers with extensive experience in the field.
The company's mission is to provide an accessible and effective preventative solution for oral health, specifically targeting populations with limited access to dental care. By replacing pathogenic bacteria with a protective layer of healthy microbes, Microversal LLC seeks to stop dental disease before it begins. The technology has been featured in dental health publications and is currently in the process of raising funds for human clinical trials following the completion of safety-focused animal studies. Microversal LLC intends to make this therapy widely available through clinical channels to improve long-term dental health outcomes.
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