OTC topical treatment for neuropathic pain using DMSO
An innovative over-the-counter topical treatment utilizing DMSO concentration, aimed at reducing neuropathic pain through decreased nociceptor excitability. Validated in preclinical and anecdotal patient trials, with plans for clinical studies in painful polyneuropathy.
Overview
This solution offers an over-the-counter (OTC) topical treatment for neuropathic pain, leveraging the properties of DMSO (dimethyl sulfoxide). The treatment is designed to address mechanical allodynia by applying a specific concentration of DMSO to the skin, which decreases the excitability of nociceptors, the pain-sensing neurons. Initial studies have shown promising results, including robust anti-allodynia effects in patients with HIV neuropathy.
Technical specifications
Key features:
- Utilizes DMSO concentration to target and reduce nociceptor excitability
- Topical application provides localized relief from mechanical allodynia
- Demonstrated efficacy in preclinical electrophysiological studies and anecdotal patient applications
Technology readiness level
This topical treatment has achieved a Technology Readiness Level (TRL) of 6, indicating that it has been demonstrated in a relevant environment. The next steps include conducting a pilot clinical study focusing on painful polyneuropathy and further development of the application technology.
About Stanford University
Stanford University is a comprehensive private research university known for cross-disciplinary scholarship and an entrepreneurial culture. Industry engages through a long-standing research park that co-locates corporate R&D with university labs, plus corporate affiliates programs and sponsored research mechanisms. Integration with a major academic medical center enables clinical translation, while shared core facilities and prototyping spaces streamline collaboration. Research is supported by competitive federal funding from agencies such as NIH, NSF, DOE, and DARPA, alongside philanthropy and industry partnerships. A dedicated Office of Technology Licensing supports IP strategy, licensing, and startup formation.
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