Peptide-based chelators for selective ferric ion chelation

Overview

Ex Seed presents an innovative approach to metal ion chelation with the development of peptide-based chelators specifically designed for ferric ions. These chelators offer a biodegradable and biocompatible alternative to traditional chelators like HEDP and DTPMP, retaining high selectivity and efficacy. The use of peptides as a scaffold ensures cost-effectiveness and environmental sustainability, making this technology highly suitable for applications in detergents and other industries requiring metal ion selectivity.

Technical specifications

The technology involves conjugating small molecule chelators such as HEDP and DTPMP to peptides like polylysine and polyglutamic acid. The process utilizes EDC/NHS coupling and phosphorylation techniques to enhance chelation efficiency and biodegradability. Key features include:

• Selective binding to ferric ions (Fe III) with high binding constants
• Biodegradability and biocompatibility confirmed through rigorous testing
• Potential adaptation for other small molecule phosphonates

Technology readiness level

Currently at Technology Readiness Level 3, the peptide-based chelators have been synthesized and are undergoing validation. This includes tests for biocompatibility using C. elegans, biodegradation in various conditions, and binding constant measurements to ensure selectivity and performance standards are met.