Peptide-based solutions for hair care targeting keratin
Advanced peptides designed using AI and computational methods to bind keratin, enhancing moisture retention and protection for hair care applications.
Overview
Delaware State University presents a cutting-edge solution in the form of peptides and miniproteins specifically designed to bind with high affinity to keratin, a vital structural protein in hair and skin. These peptides, utilizing advanced AI-driven design methods such as RFdiffusion and molecular dynamics simulations, are poised to form a stable protective layer on keratin substrates. This layer enhances moisture retention, shields against environmental damage, and delivers beneficial ingredients, significantly improving hair and skin properties. This innovation is positioned for cosmetic and therapeutic applications, offering a biocompatible and biodegradable alternative for hair care enhancement.
Technical specifications
Key features:
- AI-Driven Design: Use of RFdiffusion, ProteinMPNN, and AlphaFold for designing peptides with high binding affinity and specificity.
- Molecular Dynamics Simulations: Ensures stability and functionality of peptide-keratin complexes.
- Validation Techniques: Surface plasmon resonance and isothermal titration calorimetry validate binding affinity.
- Comprehensive Peptide Library: AI/ML deep learning model predicts high-affinity peptides, creating a robust library for further applications.
These peptides, with tailored amino acid sequences, are designed to interact specifically with keratin, offering a customizable approach to hair care.
Technology readiness level
This technology is currently at TRL 3, indicating it is in the experimental proof of concept stage. Further development and validation are planned to advance its readiness for commercial applications.
About Delaware State University
Delaware State University is a comprehensive public historically Black land‑grant university with a growing, application‑oriented research enterprise. Industry engages through co‑located campus laboratories, field and farm sites, and a statewide Extension network that provides rapid pathways for validation and deployment. The university’s central Delaware location offers access to the Mid‑Atlantic innovation corridor and proximity to Dover Air Force Base and state agencies, simplifying pilots, regulatory engagement, and workforce pipelines. Research is supported by competitive federal funding from agencies such as NSF, NIH, USDA, and the Department of Defense. A dedicated technology transfer function supports IP strategy, licensing, and industry‑sponsored research agreements, helping move solutions to market.
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